Autoimmune diseases are disorders related to the impairment of the immune system activity where the immune system interprets autogenous tissues as foreign tissues and acts to damage them. These disorders are also called “systemic disorders” since a complete system or even the body as the whole is affected.
INDICATIONS FOR THE EXAMINATION
Most often, the examination is appointed for the diagnosis of rheumatoid arthritis. This most prevalent chronic autoimmune disorder is marked by the involvement of peripheral joints where erosive destructive changes occur, as well as a wide spectrum of extra-articular manifestations.
The test also allows to distinguish between the erosive and nonerosive form of the disease. In patients with increased CPP antibodies, an increased degree of a joint’s cartilage damage is observed as compared to patients whose blood has no such antibodies. This knowledge may be used to forecast the rate of joint disintegration at earlier stages of rheumatoid arthritis, and allows the detection of AB-CPP as one of the attribute of an unfavorable prognosis for the disorder.
Combined assessment of the rheumatoid factor and AB-CPP makes is possible to diagnose rheumatoid arthritis during its earlier stages, appoint treatment in a timely manner, and prevent severe destructive changes in joints.
OUR LABORATORY PERFORMS:
Cyclic citrullinated peptide antibody (anti-CCP) analysis Normal value: (7-17) E/ml
Systemic vasculitis diagnosis
- Screening of antineutrophil antibodies (ANCAscreen hs) -- detecion of proteinase 3 (MP3) and myeloperoxidase (MPO) IgG antibodies
- Assessment of anti-myeloperoxidase (MPO) IgG antibodies that are a clinical and laboratory marker of systemic vasculitis, and are analyzed for the diagnosis and prognosis of the same.
- Detection of anti-proteinase (PR3) IgG antibodies that are a variety of neutrophil cytoplasmic antibodies ANCA and a specific serological marker of Wegener's granulomatosis.
Diagnostics of autoimmune connective tissue disorders (for the diagnosis and therapy effectiveness evaluation in patients affected by collagen disorders).
- Analysis of antinuclear antibodies (ANA) to 8 antigens - SSA 60, SS-A 52, SS-B, RNP-70, Sm, RNP/Sm and Scl-70 IgG antibody assessment, and B and Jo-1 centromer assay.
- Analysis of antinuclear antibodies (ANA) to 26 antigens - assessmet of IgG antibodies to SS-A-52 (Ro-52), SS-A-60 (Ro-60), SS-B (La), RNP/Sm, RNP-70, RNP-A, RNP-C, Sm-BB, Sm-D, Sm-E, Sm-F, Sm-G, Scl-70, Jo-1, dsDNA, ssDNA, polynucleosomes, mononucleosomes, the histon complex, histon H1, histon H2A, histon H2B, histon 3, histon H4, Pm-Scl-100 and centromer B.
- Assessment of IgG, IgА and IgM antibodies to double-stranded DNA (Anti-dsDNA screen (IgA, IgM, IgG)).
- Assessment of IgG antibodies to double-stranded DNA (Anti-dsDNA IgG).
- Assessment of IgG antibodies to SS-A 60 and SS-A 52 (Anti- SS-A).
- Assessment of IgG antibodies to and SS-B (Anti- SS-B).
- Assessment of IgG antibodies to Scl-70 (Anti-Scl-70).
- Assessment of IgG antibodies to Jo-1 (Anti-Jo-1).
Detection of thrombotic complication (antiphospholipid syndrome diagnosis)
- assessment of IgG and М antibodies to beta-2- glycoprotein
- assessment of IgG and М antibodies to cardiolipin.
Diagnosis of gastroenterological disorders
- Assessment of antibodies to М2 mitochondria antigen (AMA-M2). These specific antibodies are produced by the body as a reaction to components of autogenous cells (mitochondria), and are often revealed in cases of primary biliary cirrhosis.
- Assessment fo IgG antibodies to intrinsic factor (anti-anti-intrinsic factor) for the differential diagnosis of malignant anemia and other causes of impaired B12 vitamin absorption.
- Assessment of IgG autoimmune antibodies of class H + / K +-ATP-ase of parietal cell (Anti-Parietal Cell) for the diagnosis of autoimmune gastritis.
Liver disorder diagnostics
Assessment of IgG antibodies to the soluble form of liver cell antigen (Anti-SLA) for the purpose of diagnosis of such liver disorders as autoimmune hepatitis (AH), primary biliary cirrhosis (PBC) and various sclerosing adult and children’s cholangites.
In our studies we use automatic immunoenzymometric analyser ALEGRIA, made by Orgentec Diagnostika GmbH, Germany.
PREPARATION FOR BLOOD ANALYSIS
HOW TO TAKE A BLOOD TEST
- At the reception, conclude an agreement for the provision of paid services (if you have a referral from a doctor, show it to the medical registrar)
- Pay the invoice at the cash desk of the RCMC or via ЕРИП (SSIS: Single Settlement and Information Space)
- Get tested.
Material for research is accepted on a scheduled basis (Monday-Friday) from 8:00 to 10:00, the research results are available for the doctor and the patient from 15:00 on the same day.